物理有机化学研究惠永正

简要介绍：惠永正，男，1939年12月生，江苏苏州人，1962年毕业于北京大学化学系。后就职于中科院上海有机化学研究所、国家科委等。

中文名惠永正  

出生地江苏苏州  

出生日期1939年12月  

毕业院校北京大学  

研究领域糖化学  

人物经历  

1959.9－1962.7 北京大学

1962.9－ 中科院上海有机化学研究所

1982.2－1983.1 美国 University of North Carolina at Chapel Hill

1983.2－1983 12 美国 Rutgers University

1991.1－ 国家科委  

主要工作成就  

 惠永正早期从事物理有机化学研究，系统地研究了糖淀粉及其衍生物作为宿主体系的宿主－客体化学， 随后研究领域扩展到计算机化学和微泡体化学。近年来主要从事微泡体化学和糖化学研究，包括长链、多氟代长链化物的微泡体的性质和生物合功能模拟: 复杂寡糖的化学合成及糖缀合物中糖链与生物功能之间关系的研究。早年曾从事计算机化学和微环境效应研究，曾获全国科学大会奖(1978)，中科院科学进步一等奖(1986)，国家自然科学三等奖(1988)，和中科院发明一等奖(1997)。至今共发表论文71篇。共培养硕士研究生7，博士研究生6名，合作培养博士生8名。

发表论文  

1. Inter-Domain Movenment of Spin Lables in the Vesicle Monolayers of Hybride bolaamphiphiles.

B.Y.Z.Hui, Supramolecular Chem., 1995, 5, 193-195

2. Direct Facile Tetrahydrofuranylation of Alcohols in p-TsCl/NaH/THF System.

B.Y.Z.Hui, Synth. Commun., 1995,25, 2037

3. A New Highly Regioselective Reaction of Unprotected Sugars for Chemical Synthesis of -Acyl-D-glucopyranosides.

J.Xia, Y.Z.Hui, Synth. Commun., 1995, 25, 2235-2251

4. An Efficient and Stereospecific Synthesis of 1-Stearoyl-2-[(z,z,z)-9,12,15-Linolenoyl]-sn-Glycerophosphocholine and its Bioactivity.

J.Xia, Y.Z.Hui, Bioorg. Med. Chem. Lett., 1995,5(17),1919-1922

5. A New Strategy for the Stereoselective Synthesis of 2,3-Dideoxy-3-Fluoro-D-Ribofuranose Derivatives.

Z.W.Guo, B.G.Huang, W.J.Xia, Y.Z.Hui, S..Lang, Chin. J. Chem., 1995,13,363

6. Chemical Synthesis of a Commonly Occurring Saponin Trisaccharide: a -L-Rhaminosyl-(1-4)-b nosyl-(1-6)-D-Glucopyranose.

M.Z.Liu, Z.W.Guo, Y.Z.Hui, Carbonhydr. Lett., 1995, 1, 387-392

7. An Efficient and Stereospecific Synthesis of 1-Palmitoyl-2-[(z,z,z)-9,12,15-Linolenoyl]-sn-Glycerophophocholine.

J.Xia, Y.Z.Hui, Chin. Chem. Lett., 1995, 6(10), 863-866

8. A General Method for the Synthese of Ether Phospholipids with a -Linolenic Acid and Their Properties.

J.Xia, Y.Z.Hui, Bioorg. Med. Chem. Lett., 1995, 5(23), 2815-2820

9. A New Highly Regioselective Reaction of Unprotected Sugars for Chemical Synthesis of Methyl-6-D-Acyl-D-Glycopyranoside by Means of Chlorophosphoric Acid Diethyl Ester as Condensing Reagent.

J.Xia, Y.Z.Hui, Synth. Commun, 1996, 26(2), 269-278

10. A Convenient Method for Highly Selective Deprotection of Benzylidene Acetals from Sugars

J.Xia, Y.Hui, Synth. Commum., 1996, 26(5), 881-886

11. The TMSOTf-Promoted "One Pot" -Glycosidations of Peracetylated Chitobiose.

B.Q. Ouyang, Y.Z.Hui, J. Carbohydr. Chem., 1996, 15(3), 297-302

12. Chemical Synthesis of (3-SO3Na) GlcNAc b 1-3Fuc b 1-OMe: The Oligocaccharide Involved in the Cell Aggregation of the Sponge Microcina Prolifera.

Z.W.Guo, S.J.Deng, Y.Z.Hui, J. Carbohydr. Chem., 1996, 15(8), 965-974

13. A New Strategy for the Stereoselective Syntheses of C-Glycosyl Compounds of b -Pentapyranoses.

Z.W.Guo, Y.Z.Hui, Synth. Commun., 1996, 26(11), 2067-2073

14. Supramolecular Assemblies from Single-Chain Hydrocarbon Fluorocarbon Hybrid Bolaamphiphiles.

B. Y.Z.Hui, Chin. J. Chem., 1996, 14(2), 171-179

15. Structural Study on a Bioactive Fructan from the Root of Achyranthes Bidentata Blume.

B. G.Y.Tian, Y.Z.Hui, Chin. J. Chem., 1996, 13(6), 539-544

16. A One-Step Procedure for Facile, Selective Synthesis of Protected D-Glucopyranosides with Free 2-C Hydroxyl Group Starting from Peracetylated b-D-Glucopyranose.

; M.Z.Liu, H.N.Fan, Z.W.Guo, Y.Z.Hui,Chin. J. Chem., 1996, 14(2), 190-192

17. One-Step Glycosylation and Selective Deprotection of Peracetylated Monosaccharides for Facile Syntheses of Allyl Glycosides with a Free C-2 Hydroxyl Group.

M.Z.Liu, H.N.Fan, Z.W.Guo, Y.Z.Hui, Carbonhydr. Res., 1996, 290, 233-237

18. A New Reaction for One-pot, Selective Mono-O-Glycosylations of 9,10- Dihydroxyphenanthrene Under Mild Conditions.

Z.W.Guo, Y.Z.Hui, Chin.Chem.Lett., 1996, 7(5), 423-424

19. Isolation and Structure Elucidation of a Polysaccharide with Radiation-Protective Activity from Spinulina Platensis.

Z.W.Guo, Y.Z.Hui, Chin.J. Chem., 1996, 14(3), 279-285

20. A One-Step Procedure for Facile Preparation of D-Glucopyranosides with a Free 2-OH from Peracetylated b -D-Glucopyranose.

M.Z.Liu, H.N.Fan, Z.W.Guo, Y.Z.Hui,J. Carbohydr. Chem., 1996, 15(9), 1139-1145

21. The Stereospecific Synthesis of Mixed-acid Phospholipids with Polyunsaturated Fatty Acid from D-mannitol.

J. Xia, Y. Z. Hui, Tetrahedron: Asymmetry, 1997, 3, 451-485

22. Recent Progress of Saponin Research.

M.Z.Liu, Z.W.Guo, Y.Z.Hui, Natural Product Research and Development, 1997, 9(2), 81-85

23. A Facial Regioselective 1,6-O-Diacetylation Method of Methyl glycopyranosides and Their Dimethyl Phosphonates.

G.T.Zhang, Z.W.Guo, Y.Z.Hui, Synth. Commun., 1997, 27(11), 1907-1918

24. First Total Synthesis of Tricolorin A.

S., Q.Q.Ouyang, Z.W.Guo, , Y.Z.Hui, Angew. Chem. Int. Ed. Engl., 1997, 36, 2344-2346.

25. A Synthesis of Tricolorin A.

S., Q.Q.Ouyang, Z.W.Guo, Y.Z.Hui, J.Org.Chem., 1997, 62, 8400-8405.

26. Synthesis and Antitumor Activities of Diosgenyl Glycosides.

M.Z.Liu, , Z.W.Guo, Y.Z.Hui, Carbohydr. Lett., 1997, 2,423-428.

27. Conformational Analysis of Two Diosgenyl Saponins.

M.Z.Liu, , M.B.Chen, C.L.Feng, Y.Z,Hui, Chin. Chem. Lett., 1997, 8, 785-788.

28. A New Method for the Cleavage of Carbohydrate Benzylidene Acetyl by Ceric (IV) Ammonium Nitrate in CH3CN-H2O (10:1).

S., Q.Q.Ouyang, Z.W.Guo, , Y.Z.Hui, Chin. Chem. Lett., 1997, 8, 841.

29. Efficient One-Step Methyl Esterification of Carboxylic Acid and Deacetylation by BF3OEt2-MeOH.

S., Q.Q.Ouyang, Z.W.Guo, , Y.Z.Hui, Chin. Chem. Lett., 1997, 8, 843.

30. What is the Sugar Chains¡ˉ Function in Saponin.

M.Z.Liu, Z.W.Guo, Y.Z.Hui, Youji Huaxue, 1997, 17, 307.

31. Recent Progress on Resin Glycoside Research.

S., Q.Q.Ouyang, Z.W.Guo, Y.Z.Hui, Youji Huaxue, 1997, 17(4), 1